ID Number		2266
Study Type		In Vivo
Model		Postnatal behavioral and neurodevelopmental effects in mice exposed prenatally to mobile phone emissions.
Details		Authors' abstract: Aldad et al. 2012 (IEEE #5144): Neurobehavioral disorders are increasingly prevalent in children, however their etiology is not well understood. An association between prenatal cellular telephone use and hyperactivity in children has been postulated, yet the direct effects of radiofrequency radiation exposure on neurodevelopment remain unknown. Here we used a mouse model to demonstrate that in-utero radiofrequency exposure from cellular telephones does affect adult behavior. Mice exposed in-utero were hyperactive and had impaired memory as determined using the object recognition, light/dark box and step-down assays. Whole cell patch clamp recordings of miniature excitatory postsynaptic currents (mEPSCs) revealed that these behavioral changes were due to altered neuronal developmental programming. Exposed mice had dose-responsive impaired glutamatergic synaptic transmission onto layer V pyramidal neurons of the prefrontal cortex. We present the first experimental evidence of neuropathology due to in-utero cellular telephone radiation. Further experiments are needed in humans or non-human primates to determine the risk of exposure during pregnancy. AUTHORS' ABSTRACT: Aldad et al. 2013 (IEEE #5333): The authors identified an error in the determination of the maternal corticosterone levels as presented in Figure 4. The ELISA was repeated using stored serum samples from the original experiment. The levels have been corrected and are shown below in Figure 1 (the revised Figure 4). The mean corticosterone level in the pregnant control females was 5.4 ng/ml and in the exposed female mice was 6.1 ng/ml. There was no significant difference between the corticosterone levels of the control and experimental groups. The correction does not change the conclusions. Detailed Methods are included below and the full dataset has been uploaded as supplementary information (Supplementary Information accompanies this paper at http://www.nature.com/scientificreports).
Findings		Effects
Status		Completed With Publication
Principal Investigator		Yale University
Funding Agency		(vacant)
Country		UNITED STATES
References		Aldad, TS et al. Scientific Reports. , (Epub 2012 Mar 15) 2, 312; DOI:10.1038/srep00312 (2012):-(7 pages) Aldad, TS et al. SCIENTIFIC REPORTS., (2013) 3:DOI: 10.1038/srep01320-(1 page) Lerchl, A http://www.nature.com/srep/2012/120315/srep00312/extra/lerchl.pdf, (2013) :(4 pages) -
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