ID Number		226
Study Type		In Vivo
Model		900, 1800 MHz (CW, GSM), 2450 MHz (CW & 50 Hz AM) exposure to rats and mice and analysis of brain and liver aminoacyl-tRNA synthetase
Details		CFLP mice (pregnant dams) were exposed to 2450 MHz (CW and 50 Hz AM) for 100 minutes/day during the gestation period (19 days) at a whole body SAR of 4.23 ± 0.63 W/kg in an anechoic room (ie; far field exposure). Weight, mortality, and brain and liver aminoacyl-tRNA synthetase and transfer ribonucleic acid (tRNA) were examined on day 24. Postnatal increases of body and organ weight were not influenced by prenatal microwave exposure. Activity of brain enzymes did show a significant decrease with CW but not with AM modulated microwave exposure. The activity of enzyme isolated from liver also increased, this time with both CW and AM microwave exposure. In similar studies, both mice and rats were exposed as adults to 900 MHz (GSM) or 1800 MHz (GSM) at 20-100 uW/cm2 for 2 hr/day for 15 days. In an early report at EBEA 1998 in Croatia, 900 MHz GSM exposure resulted in a significantly higher (p<0.05) aminoacyl-tRNA synthetase activity than control. In contrast, 1800 MHz exposure aminoacyl-tRNA synthetase activity resulted in a significantly lower (p<0.05) aminoacyl-tRNA synthetase activity than control. In a later report at EBEA 2001 in Helsinki, 900 MHz (GSM) exposure did not effect either brain or liver aminoacyl-tRNA synthetase activity, and 1800 MHz (GSM) exposure now increased the activity of aminoacyl-tRNA synthetase in the liver, but had no effect on brain enzyme activity (in contrast to the EBEA 1998 report).
Findings		Effects
Status		Completed With Publication
Principal Investigator		Res. Inst. for Radiobiol & Radiohyg, Hungary - thuroczy@hp.osski.hu
Funding Agency		Ministry of Welfare, Hungary
Country		HUNGARY
References		Kubinyi, G et al. Bioelectromagnetics, (1996) 17:497-503
Comments		The results are inconsistent from one report to the next. Exposure assessment is not provided in terms of SAR. No interpretation of the data can be made.