ID Number		2186
Study Type		In Vitro
Model		0-650 Hz (including 50 Hz) ELF exposure to mouse brain synaptosome membranes and analysis of acetyl cholinesterase (AChE) activity
Details		Mouse synaptosomal membranes containing acetylcholinesterase (AChE) protein were isolated from the cerebellum and exposed to either static, 50 Hz ELF, or seveal other frequencies between 6-650 Hz. The authors report a 27% decrease in AChE activity with a threshold for an effect of 0.74 milliT, and that was frequency dependent, but not dependent upon time in the field. The effect showed a dependence that oscillated with increasing frequency, with 10, 150, 250, 400, and 575 Hz having no effect and 60, 200, 350, and 475 Hz having a maximal effect of ~27% decrease. The effect was reversible as soon as the enzyme was removed from the field. When the synaptosomal membranes were solubilized with Triton, there was no effect of ELF exposure suggesting a role of the membrane or the lipid linkage of the AChE enzyme. The authors suggest a possible health hazard of ELF exposure in developing fetus as well as a possible beneficial effect in improving cognitive performance in patients with Alzheimer's disease.
Findings		Effects
Status		Completed With Publication
Principal Investigator		University of Genoa, Italy
Funding Agency		Private/Instit.
Country		ITALY
References		Ravera, S et al. Bioelectromagnetics, (2009) :-
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