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Chicken eggs(n = 50) were exposed to 50 Hz at 1.33, 2.66, 5.52, or 7.32 milliT for 24 hours prior to incubation and evaluated upon hatching for liver histopathology and ultra-structural changes. The authors report an increase in developmental abnormalities (exencephalic, asymmetrical faces, crossed beak, shorter upper beak, deformed hind limbs, gastroschesis, anophthalmia, and microphthalmia) with exposure. Histology also indicated pathology in liver samples (cell membrane damage, fibrotic bands, steatohepatitis, vacuolizations, swollen and electron-dense mitochondria, reduced invisible cristae, crystalized mitochondria with degenerated cristae, myelin-like figures, macrophages engulfing adjacent cells, dentated nuclei, nuclei with irregular envelopes, degenerated hepatocytes, abnormal lipid accumulations, lipid droplets pushing hepatocytes' nuclei to the corner of the cells, abundant cellular infiltrations cellular infiltrations inside sinusoid and around central
veins, disrupted reticulin plexus, and release of chromatin into cytosol with
partially regular water layers). |