ID Number		2160
Study Type		In Vitro
Model		50 Hz (ELF) exposure to human and mouse cells in vitro and analysis of reactive oxygen intermediates and protein expression.
Details		Mouse macrophages (MBM) derived from bone marrow were exposed to 50 Hz ELF at 1 milliT for 5, 15, 30, or 45 minutes and analyzed for reactive oxygen species (ROS) and redox-related protein expression. TPA and E coli LPS were used as positive controls for ROS and stress response induction. The authors report a 1.4 fold increase in ROS with 45 minute exposures, with non-linear changes in certain protiens (e.g., membrane-associated subunit of the NADPH oxidase complex gp91, clathrin, P13-kinase) with certain exposure times but not others.
Findings		Effects
Status		Completed With Publication
Principal Investigator		University of Rostock, Germany
Funding Agency		Nat'l Res Prog, Germany
Country		GERMANY
References		Frahm, J et al. Toxicol Lett., (2010) 192:330-336 Mannerling, AC et al. Radiat. Environ. Biophys., (2010) 49:731-741
Comments