ID Number		2089
Study Type		In Vitro
Model		Static magnetic field exposure to rat neural progenitor cells and analysis of growth and differentiation
Details		Neural progenitor cells from embryonic rat neocortex and hippocampus were exposed to static magnetic fields at a flux density of 100 milliT. The authors report a decrease in proliferation and increase in differentiation of neural progenitor cells, with no change in cell viability. An increased expression of the c-fos/c-jun heterodimer AP-1 and several proneural genes (e.g., Mash1, Math1, and Math3), Ntan1 (essential component of the protein degradation signal), and decreased Hes5 (repressor) and MAP-2 (microtubule associated protein) expression of was also observed. The authors suggest static magnetic fields may suppress proliferation and promote neural differentiation via activator-type proneural genes.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Univ Graduate School Nat Sci Tech, Kanazawa, Japan
Funding Agency		Private/Instit.
Country		JAPAN
References		Nakamichi, N et al. J Neurosci Res, (2009) 87:2406-2417 Hirai, T et al. J Neurochem., (2006) 96:1519-1530 Hirai, T et al. J Pharmacol Sci, (2005) 98:219-224 Hirai, T et al. J Neurosci Res, (2005) 80:491-500 Hirai, T et al. J Neurosci Res., (2004) 75:230-240 Hirai, T et al. Biochem Biophys Res Commun, (2002) 292:200-207
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