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Human colon adenocarcinoma (Caco2) cells were exposed to 50 Hz (ELF) at 1 mT for 24-72 hrs and analyzed for viability, growth, reactive oxygen species, protein oxidation, and protein activity. Specifically, the authors report an activation of the 20S proteasome complex that was enhanced by co-exposure with TPA and blocked by co-exposure with the anti-oxidant EGCG, suggesting the effects of ELF exposure may have been mediated by an increase in intracellular free radicals.
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