ID Number		2010
Study Type		In Vivo
Model		900 MHz (GSM) exposure to mice (during gestation and after birth) and analysis of brain pathology
Details		Pregnant Swiss mice were exposed to 900 MHz (GSM) signals by placing a mobile phone (max reported SAR 1.2 W/kg) under the cage for 12 hrs/day (alternating standby mode for 1hr 45 min and in talk mode for 15 min) over the entire gestation period (total of 19-20 days). Following birth, randomly selected pups (n = 5) were exposed in the same way for 21 days. The authors report no significant difference in the number of pyramidal cells in the hippocampus in exposed animals. AUTHORS' ABSTRACT: Ragbetli et al. 2010 (IEEE #5634): PURPOSE: The World Health Organisation proposed an investigation concerning the exposure of animals to radiofrequency fields because of the possible risk factor for health. At power frequencies there is evidence to associate both childhood leukaemia and brain tumours with magnetic field exposures. There is also evidence of the effect of mobile phone exposure on both cognitive functions and the cerebellum. Purkinje cells of the cerebellum are also sensitive to high dose microwave exposure in rats. The present study investigated the effect of exposure to mobile phone on the number of Purkinje and granule neurons in the developing cerebellum. MATERIAL AND METHODS: Male and female Swiss albino mice were housed as control and mobile phone-exposed groups. Pregnant animals in the experimental group were exposed to Global System for Mobile Communication (GSM) mobile phone radiation at 890-915 MHz at 0.95 W/Kg specific absorption rate (SAR). The cerebella were processed by frozen microtome. The sections obtained were stained with Haematoxylin-eosin and cresyl violet. For cell counting by the optical fractionator method, a pilot study was firstly performed. Cerebellar areas were analysed by using Axiovision software running on a personal computer. The optical dissectors were systematically spaced at random, and focused to the widest profile of the neuron cell nucleus. RESULTS: A significant decrease in the number of Purkinje cells and a tendency for granule cells to increase in cerebellum was found. CONCLUSION: Further studies in this area are needed due to the popular use of mobile telephones and relatively high exposure on developing brain.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		Yuzüncu Yl University, Van, Turkey - Ragbetli@hotmail.com
Funding Agency		Private/Instit.
Country		TURKEY
References		Ragbetli, MC et al. Int J Neurosci, (2009) 119:1031-1041 Ragbetli, MC et al. Int J Radiat Biol., (2010) 86:548-554
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