ID Number		1963
Study Type		Epidemiology
Model		Cancer incidence in Norway,Denmark, Finland, and Sweden over periods of 20+ years.
Details		The incidence of meningioma in Scandinavia (Denmark, Finland, Norway, Sweden) between 1969 - 1997 was analyzed for correlations with mobile phone use. The authors report the incidence among men increased from 1.4 to 1.9 per 100,000 during the late 1970's and early 1980's, and the corresponding rates for women during this period increased from 2.6 to 4.5 per 100,000. The authors report the data provide some support for a correlation with the introduction of computed tomography detection equipment. The increasing trend in women aged 35-59 years, however, may be due to an increasing use of hormones. Quote: &little evidence that RF exposure has any effect on meningioma. In a subsequent studies the authors confirm brain tumor increases (glioma, meningioma) in Denmark, Finland, Norway, and Sweden over 1969-1998 as well as 1974-2003. The authors report increased brain tumor incidence in the late 1970's and early 1980's was due to improved diagnostic procedures and not the increase in mobile phone technology that mainly occured after 1983 and dramatically between 1998 - 2003. AUTHORS' ABSTRACT: Larjavaara et al. 2011 (IEEE #5107): BACKGROUND: The reported incidence rates of vestibular schwannomas (VS) vary substantially, but it is unclear as to what extent the variation reflects differences in risk or recording practices. Our aim was to describe the incidence rates of VS in Denmark, Finland, Norway and Sweden between 1987 and 2007. METHODS: Comprehensive data were available from all registries only for the period from 1987 to 2007. An analysis of a longer time period (19652007) was conducted with the Norwegian and Swedish data. RESULTS: The average age-standardised incidence rates during 19872007 varied from 6.1 per 1 000 000 person-years (95% confidence interval (CI), 5.46.7) among Finnish men to 11.6 (95% CI, 10.412.7) in Danish men, and from 6.4 per 1 000 000 person-years (95% CI, 5.77.0) among Swedish women to 11.6 (95% CI, 10.512.8) among Danish women. An overall annual increase of 3.0% (95% CI 2.13.9) was observed when all countries and both sexes were combined, with considerable differences between countries. However, the practices of both reporting and coding VS cases varied markedly between countries and over time, which poses a challenge for interpretation of the results. CONCLUSION: The overall incidence of VS increased in all the four Nordic countries combined between 1987 and 2007, with marked differences between countries. However, the incidence rates more or less stabilised in the late 1990s, showing relatively constant incidence rates and even some decline after 2000. AUTHORS' ABSTRACT: Deltour et al. 2012 (IEEE #5472): BACKGROUND: Some case-control studies have reported increased risks of glioma associated with mobile phone use. If true, this would ultimately affect the time trends for incidence rates (IRs). Correspondingly, lack of change in IRs would exclude certain magnitudes of risk. We investigated glioma IR trends in the Nordic countries, and compared the observed with expected incidence rates under various risk scenarios. METHODS: We analyzed annual age-standardized incidence rates in men and women aged 20 to 79 years during 1979-2008 using joinpoint regression (35,250 glioma cases). Probabilities of detecting various levels of relative risk were computed using simulations. RESULTS: For the period 1979 through 2008, the annual percent change in incidence rates was 0.4% (95% confidence interval = 0.1% to 0.6%) among men and 0.3% (0.1% to 0.5%) among women. Incidence rates have decreased in young men (20-39 years) since 1987, remained stable in middle-aged men (40-59 years) throughout the 30-year study period, and increased slightly in older men (60-79 years). In simulations, assumed relative risks for all users of 2.0 for an induction time of up to 15 years, 1.5 for up to 10 years, and 1.2 for up to 5 years were incompatible with observed incidence time trends. For heavy users of mobile phones, risks of 2.0 for up to 5 years' induction were also incompatible. CONCLUSION: No clear trend change in glioma incidence rates was observed. Several of the risk increases seen in case-control studies appear to be incompatible with the observed lack of incidence rate increase in middle-aged men. This suggests longer induction periods than currently investigated, lower risks than reported from some case-control studies, or the absence of any association.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		Cancer Registry of Norway - lars.klaeboe@kreftregisteret.
Funding Agency		Private/Instit.
Country		NORWAY
References		Deltour, I et al. J Natl Cancer Inst, (2009) 101:1721-1724 Klaeboe, L et al. Int J Cancer, (2005) 117:996-1001 Lonn , S et al. Int. J. Cancer, (2004) 108:450-455 Larjavaara, S et al. British Journal of Cancer., (2011) 105:1069-1075 Deltour, I et al. Epidemiology., (2012) 23:301-307 Deltour, I et al. Environ Int., (2022) 168:107487-
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