ID Number		1922
Study Type		In Vitro
Model		In vitro studies and review of ELF (50/60 Hz) exposure and redox pathways, viability, proliferation, apoptosis, and protein expression.
Details		Primary cortical neurons from 17-18 day old Sprague Dawley fetuses were exposed to 50 Hz fields at either 0.1 and 1.0 mT for 7 days using a solenoid coil exposure system. Cells were evaluated for neuron viability, apoptosis, total glutathione concentration, reactive oxygen species, RNA and DNA integrity, and the activity of certain enzymes. The authors report that ELF exposure increased cell viability, decreased apoptosis, and resulted in changes in brain derived neurotrophic factor (BDNF) and its receptor TrkB mRNA. A significant increase in IL-1 beta transcript and protein was observed only at 1 mT. The authors suggest ELF exposure positively affects cell viability.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Consiglio Nazionale delle Ricerche, L'Aquila, Ital
Funding Agency		Italian Space Agency
Country		ITALY
References		Di Loreto, S et al. J Cell Physiol, (2009) 219:334-343 Falone, S et al. Frontiers in Public Health. , (2018) 6:33-
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