ID Number		19
Study Type		In Vivo
Model		900 MHz (PW) exposure to mice and analysis of lymphomas (PIM-1 transgenic bioassay)
Details		C57/BL (+ CBA) transgenic (female) mice (100 per group) carrying the PIM-1 oncogene were exposed non-restrained in plastic cages (6 mice to a cage) in a pseudo-far field exposure system (via a 1/4 wavelength monopole antenna) to a 900 MHz (GSM-like) signal at 0.008 - 4.4 W/kg (whole body average) for 2 x 30 minutes/day, 7 days/week, 18 months. A 2.4 fold increase in mortality due (mainly) to B-cell lymphoma was reported.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Royal Adelaide Hospital, Adelaide Australia - repacholim@who.ch
Funding Agency		Telstra, Australia
Country		AUSTRALIA
References		Repacholi, MH et al. Radiat. Res., (1997) 147:631-640
Comments		The study is hampered by a lack of recording the disease incidence rate, a dose assessment that spans over 3 orders of magnitude, and the use of a disease endpoint (B-cell lymphoma after a 2-year exposure) that is not normally used in this model (standard endpoint is T-cell lymphoma after < 6 month exposure). It is interesting that the latest re-analysis of the original Robinette data of Korean war veterans by Grove (Am J Epidemiol (2002)155:810-818), reports a marginal increase in nonlymphoblastic lymphoma in one of the high exposure groups similar to what was found in the PIM-1 mice by Repacholi (Radiation Research (1997) 147(5):631-640), although Grove et al did not conclude these findings necessarily indicated a causative association (the magnitude of effect was small, and it was very likely just variability in the data as many tumor types were analyzed with absolutely no effect).