ID Number		1897
Study Type		In Vivo
Model		848 MHz (CDMA), 2 GHz (W-CDMA) and 915 MHz (RFID) exposure to mice and rats and analysis of testicular function, fetal development and placentan biochemistry (cortisol, mRNA expression0 and morphology.
Details		Male mice were exposed to 848 MHz (CDMA) for 2 x 45 minute exposure sessions seperated by 15 minutes each day for 12 weeks at a whole body SAR of 2.0 W/kg. The authors report no effect on sperm count in the cauda epididymis, testosterone concentration in blood serum, malonealdehyde concentration in testes and epididymus, frequency of spermatogenesis stages, germ cell counts, or apoptotic cells in the testes. There was also no effect on p21, p53, bcl-2, caspase-3 or PARP levels or phosphorylation in immunoblotting studies of testes tissue. In a related study, pregnant dams were exposed daily as above from gestation day 1 to 17 daily. 18-day old fetuses showed no effects on mortality, growth retardation, changes in head size and other morphological abnormalities. Another study exposed pregnant dams as above plus co-exposure to 2 GHz (W-CDMA) at 2 W/kg and reported no effects on mortality, growth, or morphological abnormalities. The authors conclude no observable adverse effects of exposure on rat spermatogenesis or mouse fetal development. AUTHORS' ABSTRACT: Lee et al. 2010 (IEEE 5488): We examined the histological changes by radiofrequency (RF) fields on rat testis, specifically with respect to sensitive processes such as spermatogenesis. Male rats were exposed to 848.5 MHz RF for 12 weeks. The RF exposure schedule consisted of two 45-min RF exposure periods, separated by a 15-min interval. The whole-body average specific absorption rate (SAR) of RF was 2.0 W/kg. We then investigated correlates of testicular function such as sperm counts in the cauda epididymis, malondialdehyde concentrations in the testes and epididymis, frequency of spermatogenesis stages, germ cell counts, and appearance of apoptotic cells in the testes. We also performed p53, bcl-2, caspase 3, p21, and PARP immunoblotting of the testes in sham- and RF-exposed animals. Based on these results, we concluded that subchronic exposure to 848.5 MHz with 2.0 W/kg SAR RF did not have any observable adverse effects on rat spermatogenesis.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		Korea Inst Radiol Med Sci, Korea - yslee@kcch.re.kr
Funding Agency		KCC
Country		KOREA, REPUBLIC OF
References		Lee, HJ et al. Radiat Res, (2009) 172:648-652 Lee, HJ et al. Bioelectromagnetics., (2012) 33:356-364 Lee , HJ et al. Bioelectromagnetics., (2010) 31:528-534 Kim, HS et al. Bioelectromagnetics. , (2021) 42:191-199
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