ID Number		1860
Study Type		In Vitro
Model		849 MHz (CDMA) exposure to cells in culture and analysis of proliferation, migration,invasion and protein expression.
Details		NIH3T3 cells were exposed to 849 MHz (CDMA) RF at either 2 or 10 W/kg (variation across the area of the culture dishes +/- 40%) for 1 hour on either on day or three consecutive days and evaluated for cell cycle, cell migration, and cell invasion (trans well migration) activity. The temperature in the exposure chamber was maintained isothermally by circulating water throughout the cavity. Cell cycle distribution was analyzed at 24 h and 48 h after exposure by flow cytometry. The authors report no statistically significant differences between the sham-exposed and RF radiation-exposed cells. Cellular invasion and migration were assessed by in vitro Matrigel invasion and Transwell migration assays. The RF radiation-exposed groups showed no evidence of significant changes in motility and invasiveness as compared to the sham-exposed group. However, the ionizing radiation-exposed cells, used as a positive control, manifested dramatic alterations in their cell cycle distribution, cellular invasiveness, and migration characteristics.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		Korea Inst Rad Med Sci, Seoul, Korea - jaeslee@kcch.re.kr
Funding Agency		EMF Project, Korea, MIC Korea, ETRI, Korea
Country		KOREA, REPUBLIC OF
References		Lee, JJ et al. Bioelectromagnetics, (2008) 29:615-625 Kim, KB et al. J Radiat Res (Tokyo)., (2010) 51(2):205-213
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