ID Number		1859
Study Type		In Vivo
Model		2.1 and 1.95 GHz (W-CDMA) exposure to rats and analysis of teratogenicity and reproduction
Details		Sprague Dawley rats (n = 36 pregnant dams) were exposed to 2 GHz W-CDMA for 90 min/day at an SAR of 2 or 0.67 W/kg (brain average) in the pregnant dams (0.4 W/kg whole body including the fetus), with exposure running from gestation day 7 through 17. Pregnant rats were sacrificed on day 20, fetuses removed and analyzed. The authors report no effect on several morphological and pathological endpoints, and suggest no observable effect of RF exposure during gestation on teratogenesis. In a related study, the authors exposed free moving pregnant Crl:CD(SD) rats from the 7th day of gestation through day 21 postpartum to 2.14 GHz (UMTS) base station signals for 20 hr/day with calculated whole body average SARs of 0.066-0.093 W/kg (high dose) or 0.028-0.040 W/kg (low dose) for dams and 0.068-0.146 W/kg (high dose) or 0.029-0.067 W/kg (low dose) for the fetuses. F1 offspring were also crossed and exposed as above. The authors report no effect of exposure on body-weight, food consumption, gestation period, fertility, organ weights, development, memory function, hormone status, or gross abnormalities. AUTHORS' ABSTRACT: Shirai et al. 2016 (IEEE #6523): In everyday life, people are exposed to radiofrequency (RF) electromagnetic fields (EMFs) with multiple frequencies. To evaluate the possible adverse effects of multifrequency RF EMFs, we performed an experiment in which pregnant rats and their delivered offspring were simultaneously exposed to eight different communication signal EMFs (two of 800 MHz band, two of 2 GHz band, one of 2.4 GHz band, two of 2.5 GHz band and one of 5.2 GHz band). Thirty six pregnant Sprague-Dawley (SD) 10-week-old rats were divided into three groups of 12 rats: one control (sham exposure) group and two experimental (low- and high-level RF EMF exposure) groups. The whole body of the mother rats was exposed to the RF EMFs for 20 h per day from Gestational Day 7 to weaning, and F1 offspring rats (46-48 F1 pups per group) were then exposed up to 6 weeks of age also for 20 h per day. The parameters evaluated included the growth, gestational condition and organ weights of the dams; the survival rates, development, growth, physical and functional development, memory function, and reproductive ability of the F1 offspring; and the embryotoxicity and teratogenicity in the F2 rats. No abnormal findings were observed in the dams or F1 offspring exposed to the RF EMFs or to the F2 offspring for any of the parameters evaluated. Thus, under the conditions of the present experiment, simultaneous whole-body exposure to eight different communication signal EMFs at frequencies between 800 MHz and 5.2 GHz did not show any adverse effects on pregnancy or on the development of rats.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		Nagoya City University Medical School, Japan - tshirai@med.nagoya-cu.ac.jp
Funding Agency		MIC, Japan
Country		JAPAN
References		Takahashi, S et al. Radiat Res, (2010) 173:362-372 Ogawa, K et al. Bioelectromagnetics, (2009) 30:205-212 Imai , N et al. Syst Biol Reprod Med., (2011) 57:204-209 Shirai, T et al. J Radiat Res., (2017) 58:48-58
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