ID Number		1809
Study Type		Human / Provocation
Model		Mobile phone exposure to volunteers and evaluation of micronuclei formation in buccal epithelial cells
Details		Human subjects (n = 109) were evaluated for mobile phone use and evaluated for micronucleus formation and chromosome abnormalities in a sample of buccal epithelial cells. The "exposed" group had significantly higher micronucleated cells that non-mobile phone users, with a dose response for duration of mobile phone use. AUTHORS' ABSTRACT: Gulati et al. 2016 (IEEE #6393): All over the world, people have been debating about associated health risks due to radiation from mobile phones and mobile towers. The carcinogenicity of this nonionizing radiation has been the greatest health concern associated with mobile towers exposure until recently. The objective of our study was to evaluate the genetic damage caused by radiation from mobile towers and to find an association between genetic polymorphism of GSTM1 and GSTT1 genes and DNA damage. In our study, 116 persons exposed to radiation from mobile towers and 106 control subjects were genotyped for polymorphisms in the GSTM1 and GSTT1 genes by multiplex polymerase chain reaction method. DNA damage in peripheral blood lymphocytes was determined using alkaline comet assay in terms of tail moment (TM) value and micronucleus assay in buccal cells (BMN). There was a significant increase in BMN frequency and TM value in exposed subjects (3.65 ± 2.44 and 6.63 ± 2.32) compared with control subjects (1.23 ± 0.97 and 0.26 ± 0.27). However, there was no association of GSTM1 and GSTT1 polymorphisms with the level of DNA damage in both exposed and control groups. AUTHORS' ABSTRACT: Gulati et al. 2017 (IEEE #6803): In the present era, cellular phones have changed the life style of human beings completely and have become an essential part of their lives. The number of cell phones and cell towers are increasing in spite of their disadvantages. These cell towers transmit radiation continuously without any interruption, so people living within 100s of meters from the tower receive 10,000 to 10,000,000 times stronger signal than required for mobile communication. In the present study, we have examined superoxide dismutase (SOD) enzyme activity, catalase (CAT) enzyme activity, lipid peroxidation assay, and effect of functional polymorphism of SOD and CAT antioxidant genes against mobile tower-induced oxidative stress in human population. From our results, we have found a significantly lower mean value of manganese superoxide dismutase (MnSOD) enzyme activity, catalase (CAT) enzyme activity, and a high value of lipid peroxidation assay in exposed as compared to control subjects. Polymorphisms in antioxidant MnSOD and CAT genes significantly contributed to its phenotype. In the current study, a significant association of genetic polymorphism of antioxidant genes with genetic damage has been observed in human population exposed to radiations emitted from mobile towers.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Kurukshetra University, India
Funding Agency		Private/Instit.
Country		INDIA
References		Yadav, AS et al. Mutation Research, (2008) 650:175-180 Gulati, S et al. Arch Environ Contam Toxicol., (2016) 70:615-625 Gulati, S et al. Mol Cell Biochem., (2018) 440:1-9
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