ID Number		1804
Study Type		In Vivo
Model		835 MHz (CW) exposure to Drosophila melanogaster and evaluation of gene expression and viability.
Details		Drosophila melanogaster (4 different strains - two of which had loss of SOD function, all flies at 3 days old) were exposed to 835 MHz (CW) at 1.6 or 4.0 W/kg (presumably whole body) for 18 or 30 hours using a V10 waveguide system (?), with temperature maintained at 25 degrees C. The authors report 90% viability at 1.6 W/kg for 30 hours and only 10% viability at 4.0 W/kg for 30 hours. The authors report increased hsp27 and hsp70 at both exposure levels (suggesting a stress response), increase in reactive oxygen radicals in a dose dependent manner, ERK phosphorylation / activation was higher at 1.6 W/kg (suggesting increased growth / development), JNK phosphorylation / activation was higher at 4.0 W/kg (suggesting increased apoptosis), and no changes in p38. Bcl-2 (anti-apoptotic) expression was also increased with 1.6 W/kg, but p53, reaper, and hid (apoptotic) increased after 4.0 W/kg exposure. Increased apoptotic activity in the brain was also detected at 4.0 W/kg by TUNEL assay.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Soonchunhyang University, Korea
Funding Agency		KORSEF, Korea
Country		KOREA, REPUBLIC OF
References		Lee, KS et al. Bioelectromagnetics, (2008) 29:371-379
Comments		1.6 and 4.0 W/kg whole body is significantly higher than the IEEE C95.1 limit of 0.08 and 0.4 W/kg for whole body exposure (general public, occupational, respectively)