ID Number		1788
Study Type		In Vivo
Model		900 Mhz (GSM) exposure to Ptc1+/- mice and evaluation of tumorogenesis
Details		Patched1 heterozygous knockout mice (n = 200 Ptc1+/-; sonic hedgehog homologue - predisposed to multiple tumors that is accelerated by ionizing radiation) were exposed to 900 MHz (GSM) RF as newborns for 30 minutes per day, 5 days at a whole body average SAR of 0.4 W/kg. Patched1 is involved constituitively in regulating cerebellar development, and loss of shh / ptc-1 results in meduloblastomats in cerebellum, basal cancer carcinomas in skin (epidermal proliferation disorder) and rhabdomyocarcinoma. In teh present study, RF exposure did not affect survival rate or the incidence or histology of tumors. Basal cell skin proliferation was also examined and found not to be affected by RF exposure.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		Dept of Environment / ENEA, Italy - marino@casaccia.enea.it
Funding Agency		Private/Instit.
Country		ITALY
References		Saran, A et al. Radiation Research, (2007) 168:733-740
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