ID Number		1741
Study Type		In Vivo
Model		10 MHz (CW) expsoure to rats in combination with 2-methoxyethanol and analysis of teratogenic effects
Details		Rats were exposed to 10 MHz (CW - sufficient to increase core body temperature to 42 degrees) in combination with 2-methoxyethanol. Initial studies reported synergistic action of RF hyperthermia and 2-ME in generating fetal malformations. Follow-on studies were performed co-exposing rats as above for 3, 6, 24, or 48 hours followed by immediate evaluation of 2-ME teratogenic metabolites (MAA) as well as protein adduct formation in tissues. The authors report RF hyperthermia did reduced clearing of MAA metabolites, but did not increase adduct formation or metabolite levels in blood, urine, or tissues. The authors conclude synergistic effects are not the result of covalent binding in the embryo.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		CDC, NIOSH, Cincinnati OH - klc1@cdc.gov
Funding Agency		NIOSH, USA
Country		UNITED STATES
References		Cheever, KL et al. Toxicol Lett, (2001) 122:53-67 Nelson, BK et al. Teratology, (1991) 43:621-634 Nelson, BK et al. , (1994) 50:275-293 Nelson, BK et al. Journal of applied toxicology., (1997) 17:31-39 Nelson, BK et al. Developmental toxicity interactions of methanol and radiofrequency radiation or 2-methoxyethanol in rats., (2001) 20:89-100
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