ID Number		172
Study Type		Epidemiology
Model		INTERPHONE - Danish National site 900, 1800 MHz (NMT, GSM, W-CDMA) mobile phone use and correlation with brain, acoustic nerve, parotid gland tumors
Details		In an initial 12 month pilot case control study, human subjects were analyzed for brain, salivary gland, and auditory nerve tumors (acoustic neuromas) and mobile phone use. Christensen et al (2004) looked at associations between acoustic neuroma and mobile phone use for 10 years or more and acoustic neuromas. The study included 106 cases between 2000-2002 and found no correlation(OR=0.9, 95% CI 0.5-1.6). In related studies, the authors investigated correlations between mobile phone use and glioma and/or meningioma. Again, cases included those diagnosed in Denmark between September 1, 2000 and August 31, 2002 aged 20 to 69 (n = 252 gliomas and n = 175 meningiomas, n = 822 controls matched for age and sex). Exposure assessment was performed via personal interviews and, for a small number of cases, via billing records. Memory of the respondents was evaluated with the Mini-Mental State Examination, and data on socioeconomic factors from was also obtained. The authors report use of mobile phones associated with a decreased risk of high-grade glioma (OR = 0.58; 95% CI 0.37-0.90) and no association with low-grade glioma (OR = 1.08; 95% CI 0.58 - 2.00) or meningioma (1.00; 0.54 to 1.28). The authors conclude no apparent association between mobile phone use and the risk of glioma or meningioma. Overall study findings: OR = 0.58; 95% CI 0.37-0.90 - high-grade glioma, OR = 1.08; 95% CI 0.58-2.00 - low-grade glioma, OR = 1.00; 95% CI 0.54-1.28  meningioma, OR = 0.90; 95% CI 0.51-1.57 - acoustic neuroma, no ipsilateral association, insufficient 10+ yr users for evaluation.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		Danish Cancer Society, Denmark - christof@cancer.dk
Funding Agency		EU, INTERPHONE (IARC) coordinated studies, CS, Denmark, Nat'l Res Prog, Denmark, MMF, GSM Association
Country		DENMARK
References		Christensen, H Neurology, (2005) 64:1189-1195 Christensen , HC et al. Am J Epidemiol, (2004) 159:277-283 Hardell, L et al. Am J Epidemiol., (2004) 160:923-926 Hardell, L Evidence-based Healthcare, (2004) 8:213-215
Comments		THe authors do report a statistically significant PROTECTIVE effect with high grade gliomas and mobile phones, but no dose response either with time (advent of digital / lower average power and DTx which would have reduced exposure - although minutes of use might have been much higher) or time and/or intensity of use.