ID Number		16
Study Type		In Vivo
Model		900 MHz (GSM) exposure to mice and analysis of cancer (UV-initiated skin tumors in ODC transgenic & non-transgenic mice)
Details		Balb/c x DBA/2 hybrid mice (both wild type and ODC overexpressing transgenics from line K2 [J. Biol. Chem, 1991, 266:19746-51]) were initiated for skin tumors with UV radiation (@ 1.2 minimum erythemal dose) 3x per week and exposed to 900 MHz (GSM and DAMPS) RF for 1.5 hours/day, 5 days/week for 1 year at 0.5 W/kg (whole body average) in rectangular waveguides. No effects on body weight, survival, urinary 6-hydroxymelatonin sulphate (6-OHMS)levels, polyamine levels, or ODC activity. The authors report skin tumor development appeared slightly accelerated especially in RF exposed non-transgenic mice, but the results were not statistically significant. Also, RF exposure did not affect excretion of 6-OHMS into urine or polyamine levels in skin. The authors concluded that RF exposure did not enhance skin tumorgenesis.
Findings		No Effects
Status		Completed With Publication
Principal Investigator		University of Kupio, Finland - Jukka.Juutilainen@uku.fi
Funding Agency		Nat'l Res Prog, Finland
Country		FINLAND
References		Heikkinen , P et al. Int J Radiat. Biol., (2003) 79:221-233
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