ID Number		1531
Study Type		In Vivo
Model		2450 MHz(CW) exposure to rat brains at hyperthermic levels (using implanted MW applicators) and analysis of tissue damage and blood flow
Details		Rats were exposed to 2450 MHz (CW) at hyperthermic levels (maintaining temeratures of 40, 41, 42, 43, and 44 degrees C, respectively) for 30 minutes using a helical coild antenna inserted into the frontal white matter of the brain. Hyperthermic damage, changes in cerebral blood flow, and tissue vascularity were assessed over a 6 week period using brain CT scans. TIssue necrosis occured at 43.9 +/- 1.5 degrees C and was maximal at 1 week following hyperthermia. Heating (non-necrotic) in the brain stimulated a rapid vascular response, with decreased blood flow in heated brains was reduced for the first 3 weeks but returned to normal at 4 weeks with an increase in vascularity.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		Univ California, San Francisco, USA
Funding Agency		NIH, USA
Country		UNITED STATES
References		Fike, JR et al. Int J Hyperthermia, (1991) 7:795-808
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