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EMF Study
(Database last updated on Mar 27, 2024)

ID Number 1474
Study Type In Vitro
Model 60 Hz (pulsed) exposure to bone cells and analysis of DNA synthesis and proliferation
Details

Osteosarcoma cell lines (TE-85, MG-63) and normal human osteoblast cells from surgical bone specimens were exposed to pulsed 60 Hz (1.3 msec pulse width, repeated at 75 Hz) for different times and analyzed for effects on proliferation. The authors report stimulation of DNA synthesis with normal human osteoblasts responding more rapidly to pulsed ELF than established cell lines. Other studies reported similar effects of pulsed 60 Hz on increasing DNA synthesis in articular chondrocytes. The authors speculate the importantce of their findings with respect to stimulation of fracture healing. The authors also report corresponding changes in gene expression and proteoglycan synthesis.

Findings Effects
Status Completed With Publication
Principal Investigator Dipartimento di Morfologia ed Embriologia, Univers - dmm@dns.unife.it
Funding Agency Agency Tech, Energy, Environ, Italy
Country ITALY
References
  • De Mattei, M et al. Bioelectromagnetics, (2005) 26:207-214
  • De Mattei, M et al. Osteoarthritis Cartilage, (2004) 12:793-800
  • De Mattei, M et al. Connective Tissue Research, (2003) 44:154-159
  • De Mattei, M et al. Connective Tissue Research, (2001) 42:269-279
  • De Mattei, M et al. Bioelectromagnetics, (1999) 20:177-182
  • Pezzetti, F et al. Calcif Tissue Int, (1999) 65:396-401
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