ID Number		145
Study Type		Human / Provocation
Model		900 MHz (GSM) exposure to humans and analysis of EEG, sleep, and auditory evoked potentials.
Details		In initial studies, human subjects (n=8) were exposed to 900 MHz (GSM) signals for ~ 2 hours/day, 5 days/week, for 4 weeks. Sleep and EEG patterns were compared against pre-exposure measurements (self-controls). No effects of RF were observed for sleep time, sleep stage latency and time, wakefulness after sleep, or sleep efficiency. In addition, no effects were observed in EEG recordings in the spectral bands of 0.5 to 25 Hz or in the exponential decay of slow brain activity. Subsequent studies looked at human subjects (healthy volunteers and patients with right temporal lobe epilepsy) exposed to 900 MHz (GSM) RF at an SAR of 1.4 W/kg using a fixed mobile phone at the right ear with power controlled via a base station simulator. Each subject was tested in a Faraday room and underwent 2 blinded sessions (1 exposed, 1 sham, and thus served as their own control). Auditory evoked potentials triggered by a test tone (500 tones, 1 per second, half at 500 Hz and half at 1 kHz) were measured during RF exposure periods using a 32 electrode cap. The authors report for healthy volunteers, RF exposure resulted in an overall increase in the mean change over all electrode pairs (called " Temporal Correlation Variation"), although the individual data showed 5 increases, 2 decreases, and 2 unchanged. In epileptic patients, the authors report an overall decrease in Temporal Correlation Variation, although again individual data was variable, with 3 decreases, 2 increases, and 2 unchanged. In a subsequent 2006 report, the authors report additional changes in the different spectral bands (alpha, beta, theta, delta) and also suggest significant differences between healthy volunteers vs. epileptic patients that make them difficult to compare directly, but differences between unexposed and exposure were observed. Specifically, authors reported latency decreases in auditory and right parietal regions in healthy volunteers, suggesting a faster reaction to stimulus and supporting previous findings of Preece et al (1999). The authors conclude that RF changes might suggest effects on cognitive function during auditory processing, although this or links to other health endpoints cannot be confirmed from the present data. AUTHORS' ABSTRACT: The aim of the present work was to investigate the effects of the radiofrequency (RF) electromagnetic fields (EMFs) on human resting EEG with a control of some parameters that are known to affect alpha band, such as electrode impedance, salivary cortisol, and caffeine. Eyes-open and eyes-closed resting EEG data were recorded in 26 healthy young subjects under two conditions: sham exposure and real exposure in double-blind, counterbalanced, crossover design. Spectral power of EEG rhythms was calculated for the alpha band (8-12 Hz). Saliva samples were collected before and after the study. Salivary cortisol and caffeine were assessed by ELISA and HPLC, respectively. The electrode impedance was recorded at the beginning of each run. Compared with the sham session, the exposure session showed a statistically significant (P < 0.0001) decrease of the alpha band spectral power during closed-eyes condition. This effect persisted in the postexposure session (P < 0.0001). No significant changes were detected in electrode impedance, salivary cortisol, and caffeine in the sham session compared with the exposure one. These results suggest that GSM-EMFs of a mobile phone affect the alpha band within spectral power of resting human EEG.
Findings		Effects
Status		Completed With Publication
Principal Investigator		University of Rennes, France - biomed@zeus.sc.univ-montpl.fr
Funding Agency		France Telecom/CNET, CoMoBio, France
Country		FRANCE
References		Maby, E et al. Conf Proc IEEE Eng Med Biol, (2006) 1:3751-3754 Maby, E et al. Int J Radiat Biol, (2006) 82:465-472 Maby, E et al. Bioelectromagnetics, (2005) :- de Seze, R J Sleep Research, (2000) 9(Suppl 1):18- Ghosn , R et al. J Neurophysiol., (2015) 113:2753-2759 Selmaoui, B et al. International Journal of Radiation Biology., (2018) 94:890-895 Wallace, J et al. Environmental Research., (2019) 175:274-286 Besset, D et al. Environ Res., (2019) :108894- Wallace, J et al. Int J Radiat Biol., (2022) 98:986-995 Wallace, J et al. Sci. Rep., (2021) 11:23403-
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