ID Number		1443
Study Type		In Vivo
Model		20 kHz exposure to mice (prenatally) and anaysis of brain growth and gene expression
Details		C57/B1 mice were exposed during pregnancy (gestation days 0-19) to 20 kHz magnetic field with an asymmetric sawtooth-waveform at 15 microT (peak to peak) (no dose information available). After 19 days exposure was terminated and the mice were housed individually under normal laboratory conditions. On postnatal day 1, 21, and 308 various neurochemical markers in the brains of the offspring were investigated and brains weighed. No effect of exposure on brain weight or protein, DNA, nerve growth factor, acetylcholine esterase, or 2',3'-cyclic nucleotide 3'-phosphodiesterase (marker for oligodendrocytes) activities. On PD308, a significant decrease in total brain weight was reported with exposure, although no differences in individual brain regions (cortex, hippocampus, septum, cerebellum) vs. sham exposed brains was reported. Also on PD 308, decreased DNA and increased activities of CNP, AChE, and NGF were observed in the cortex and cerebellum. The authors report these effects to be similar to those induced by ionizing radiation, but much weaker and the duration of exposure required to trigger the responses is greater and effects appear later during development than with ionizing radiation.
Findings		Effects
Status		Completed With Publication
Principal Investigator		University of Agricultural Sciences, Uppsala, Swed
Funding Agency		Private/Instit.
Country		SWEDEN
References		Dimberg, Y Bioelectromagnetics, (1995) 16:263-267
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