ID Number		1403
Study Type		In Vivo
Model		64 MHz (MRI signal) exposure to rats and analysis of blood brain barrier permeability
Details		Rats (nephrectomized and i.v. injected with tritiated mannitol) were exposed to 64 MHz (MRI signals) at 1.5, 0.5, and 0.3 T and analyzed for brain mannitol concentration. The authors report significant increases with exposure at 0.3 T and 0.5 T but not at 1.5 T. Further, exposure to 0.3 T with gradient-field fluctuations used for imaging increased brain mannitol concentration, but exposure to 0.3 T using static main field and pulsed RF did not. The authors speculate that the effect may be related to increased blood-brain barrier permeability or blood volume in brain. The authors further suggest that their results are consistent with prior evidence of an MRI-induced increase of brain capillary endothelial cell transport observed with horseradish peroxidase.
Findings		Effects
Status		Completed With Publication
Principal Investigator		UCLA School of Medicine, USA
Funding Agency		NIH, USA
Country		UNITED STATES
References		Garber, HJ et al. Magn. Reson. Imaging, (1989) 7:605-610
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