ID Number		1357
Study Type		In Vitro
Model		900 MHz (CW) exposure to liposomes and analysis of permeability and changes in molecular structure
Details		Liposome bilayers (formed on the glass walls of a pyrex flask and maintained above phase transition temperature) were exposed to 900 MHz (CW) RF for 5 hours at an SAR of 12 +/- 1 W/kg from a magnetron. Membrane permeability, liposome size, and pore formation (leakage) was assessed using light-scattering techniques. Temperature in the exposed sample rose from 29 to ~ 33 degrees C at 50 minutes of exposure and remained relatively constant for the remaining 4 hours and 10 minutes. The authors report that exposure increased membrane permeability and the rate of "disorder" in hydrocarbon acryl chains. MRI analysis also revealed a change in the molecular structure of the hydrocarbon acyl chains. The authors suggest RF may lead to hydrolysis (breaking of carbyl - phospholipid bonds) forming hydrogen peroxide that could undermine the structure and function of the membrane.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Cairo University, Giza, Egypt
Funding Agency		Private/Instit.
Country		EGYPT
References		Gaber, MH et al. Bioelectromagnetics (2005) 26(3):194-200, (2005) 26:194-200
Comments		Clearly at 12 W/kg and a reported temperature increase of >4 degrees, there could have been significant hot spots resulting in all kinds of lipid and memberane changes.