ID Number		1305
Study Type		In Vitro
Model		2450 MHz exposure to primary murine bone marrow cells at hyperthermic levels and in combination with Misonidazole and X-rays, and analysis of SCE
Details		Primary bone marrow cells from treated dbrB tumor-bearing DBA/1J inbred mice were exposed to microwave hyperthermia as well as Misonidazole (MIS - a radiosensitizing drug) and/or X-rays and analyzed for the frequency of sister chromatid exchanges (SCE). All three treatments (MIS + delta + X) simultaneously resulted in a statistically significant increase in SCE vs. untreated tumor-bearing mice. In further studies using a s.c. implanted mammary adenocarcinoma in female DBA/1J mice, treatment with all three agents combined resulted in increased survival.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator
Funding Agency		Private/Instit.
Country		UNITED STATES
References		Banerjee, R et al. J. Natl. Cancer Inst., (1983) 70:517-521 Banerjee , R et al. Cancer Res., (1983) 43:2210-2215
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