ID Number		1302
Study Type		In Vitro
Model		1 GHz (CW), 2450 MHz (CW) exposure to cancer cells in vitro and in xenografted mice following cancer cell injection and analysis of DNA synthesis and chemotherapy augmentation
Details		In an early study, L1210 murine leukemia cells were exposed to 1 GHz (CW, PW) RF at an average power density of 10 mW/cm2 +/- methotrexate (MTX) and analyzed for DNA breaks and inhibition of DNA synthesis in vitro, as well as the efficacy of MTX to inhibit the progression of L1210 leukemia in xenografted mice injected. Exposure alone for 20 minutes resulted in a decreased DNA synthesis in cells in vitro. Exposure + [3H]MTX resulted in in enhanced drug uptake and augmentation of the MTX decrease in DNA synthesis. Combined treatment of L1210-bearing mice prolonged survival over that of animals treated with MTX alone, indicating a greater killing of leukemia cells. The authors suggest possible improvement of MTX therapeutic index with MW exposure at low power densities. In subsequent studies, thermal levels of 2450 MHz exposure were used to study possible anticancer effects and augmentation of anticancer drugs.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		Duke University, USA
Funding Agency		NIH, USA
Country		UNITED STATES
References		Chang, BK et al. Bioelectromagnetics, (1987) 8:195-202 Chang, BK et al. Bioelectromagnetics, (1981) 2:77-80 Chang, BK et al. Cancer Res., (1980) 40:1002-1005
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