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(Database last updated on Mar 27, 2024)
| ID Number | 13 | |
| Study Type | In Vivo | |
| Model | 929 & 1500 MHz (PDC) exposure to rats and analysis of cancer (DEN induced-GSTp(+) hepatoma bioassay) | |
| Details | Fisher 344 (male) rats were given a 2/3 hepatectomy at week 3 and injected i.p. with 200mg/kg diethyl nitrosourea (DEN) at week 6 to induce hepatomas. Rats were exposed to a 929 MHz (PDC) signal in the near field under restrained conditions (1cm from antenna in a tube holder) for 90min/day, 5 days/wk, for 6 weeks. SAR values (1.7 - 2.0 W/kg maximal in the liver, 0.6 - 0.8 W/kg whole body average, and 6.6 - 7.2 W/kg peak) were recorded. No statistically significant difference was observed in liver tumor foci (by GST - P immunostaining) between sham and exposed groups, although moderate increases in exposure vs. sham were reported in serum ACTH & corticosterone (stress), and melatonin levels. In a second similar study using 1.5 GHz PDC exposure for 90min/day, 5 days/wk, for 6 weeks at SARs of 2.0 W/kg maximal in the liver, 0.7 W/kg whole body average, again no statistically significant difference was observed in liver tumor foci by GST - P immunostaining. The authors did follow up a non-significant decreased trend in liver foci by evaluating the effects of different levels of melatonin administration (1, 5, l0 and 20 ppm in the drinking water) over a period of 8 weeks using the same study system. The authors report increases in melatonin and decreases in LH and FSH, although not with any obvious dose response. GST-P-positive liver foci were also decreased by melatonin treatment. The authors speculate that any slight effect RF exposure did have on decreasing tumor foci might have been due to a mechanism involving melatonin. |
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| Findings | No Effects | |
| Status | Completed With Publication | |
| Principal Investigator | Nagoya City University Medical School, Japan - shirai@med.nagoya-cu.ac.jp | |
| Funding Agency | ARIB, Japan | |
| Country | JAPAN | |
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