ID Number		1111
Study Type		In Vivo
Model		2450 MHz (CW) exposure to red blood cells and analysis of oxidative stress
Details		Sheep RBCs were exposed to 2450 MHz (CW) RF at an SAR of 91 W/kg for 10 minutes at temperatures of 25, 37, 40, 42, and 45 degrees. Exposure at high SAR had no effect on NADH oxidase activity under temperature controlled conditions, although hyperthermia-induced auto-oxidation of RBCs and release of superoxide and peroxides at elevated temperature could be partially reversed by co-exposure with reducing compounds. In a related study, the effect of 2450 MHz at an SAR of 103 W/ kg was studied on glucose oxidase conversion of partially purified human oxyhemoglobin to methemoglobin. As controls, base (pH 10), heat (50 degrees C), and hydrogen peroxide (5.6 mM) were all effective in promoting the oxidation conversion. MW exposure inhibited thermally induced autooxidation by 28.6%, but did not affect oxidation by hydrogen peroxide.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		Brooks Air Force Base, TX, USA - johnathan.kiel@aloer.brooks.af.mil
Funding Agency		AF, USA
Country		UNITED STATES
References		Kiel, JL et al. Physiol. Chem. Phys. Med. NMR, (1988) 20:123-128 Kiel, JL et al. Int. J. Hyperthermia, (1986) 2:201-212 Kiel, JL et al. Am. J. Veterinary Res, (1986) 47:2155-2160 Kiel, JL et al. Physiological Chemistry Physics Medical NMR, (1986) 18:181-187 Kiel, JL et al. Physiol. Chem. & Phys. & Med. NMR, (1984) 16:317-323 Armstrong, DL et al. , (1991) :-
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