ID Number		111
Study Type		In Vitro
Model		147, 915 MHz (AM-16Hz, CW) exposure to cell lines and analysis of signaling pathways
Details		Neuroblastoma human cells (IMR-32) were exposed to to 915 MHz RF (CW or PW with 80% sinusoidal amplitude modulation at 16 Hz) for 30 minutes at SARs of 0, 0.01, 0.05, 0.075, 0.1, 0.5, 0.75, 1.0, 1.5, 2, or 5 W/kg. Increased calcium (45Ca++) efflux was reported following exposure to 915 MHz RF (PW) at 0.05, 0.75 and 1 W/kg (maximal at 1.0 W/kg) with no increase at 0.5, 1.5, or 2 W/kg. This unusual dose-response was interpreted by the authors as power-density "windows". In other studies not using cellular telephone RF frequencies (Bioelectromagnetics 1989, 10(2):197-202), the group reported chick brain tissues exposed to 147 MHz RF for 20 minutes at power densities of 0.11, 0.55, 0.83, 1.11, 1.38, and 1.66 mW/cm2 changed the degree of calcium-ion binding. In NG108-15 cells exposed 30 minutes to 147 MHz at up to 0.1 W/kg, (Bioelectromagnetics, 1992, 13(4):317-322) either enhanced or reduced AChE activity (depending upon the SAR) was observed. Specifically, enhanced AChE activity (p<0.01) occurred at 0.05 and 0.02 W/kg, while significantly lower AChE activity occured at 0.01 W/kg. At 0.001, 0.005 W/kg and 0.01 W/kg, no significant effects on AChE activity were reported.
Findings		Effects
Status		Completed With Publication
Principal Investigator		Howard University, USA - sdutta@fac.howard.edu
Funding Agency		EPA, USA
Country		UNITED STATES
References		Dutta, SK et al. Bioelectromagnetics, (1984) 5:71-78 Dutta, SK et al. Bioelectromagnetics, (1989) 10:197-202 Dutta, SK et al. Bioelectromagnetics, (1992) 13:317-322 Dutta, SK et al. BIOLOGICAL EFFECTS OF ELECTROPOLLUTION--BRAIN TUMORS AND EXPERIMENTAL MODELS [BOOK]., (1986) :63-69
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