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(Database last updated on Mar 27, 2024)
| ID Number | 1029 | |
| Study Type | In Vivo | |
| Model | 112 MHz (AM-16 Hz), 2450 MHz (CW) and 9.9 GHz exposure to rats and analysis of protein activity in the brain | |
| Details | Wistar rats were exposed to 112 MHz (AM-16 Hz) for 2 hrs/day for 35 days at 0.75 W/kg (beginning at day 35). Exposure resulted in enhanced ornithine decarboxylase activity and Ca2+ efflux in brain tissue. In related studies, Wistar rats (n = 6) were exposed as above (2 hrs/day, 35 days) to either 112 MHz (AM 16 Hz) or 2450 MHz (CW). Exposures at 112 MHz (AM 16 Hz) had predicted whole body SAR values of 1.48 W/kg, and 2450 MHz (CW) exposures had predicted whole body SAR values of 0.11 W/kg. At the end of the exposure series, brain tissue was assayed for protein kinase C (PKC) assay. The authors report both types of exposure resulted in decreased PKC activity in the hippocampus compared to the rest of the exposed brain and as compared to the non-exposed control hippocampus.The authors also report increased glial cell numbers in exposed rats. The authors suggest these results amy indicate potential health hazards due to RF exposure. AUTHORS' ABSTRACT: Paulraj and Behari 2012 (IEEE #5154): Present study concerns with various biochemical changes in the developing rat brain exposed to 9.9 GHz (square wave modulated, 1 kHz) at power density 0.125 mW/cm(2) (specific absorption rate 1.0 W/kg) for 2 h/day for 35 days. Thirty days old male wistar rats were used for this present study. Each group consists of eight animals. After the exposure, biochemical assays such as calcium ion efflux, calcium-dependent protein kinase (PKC), and ornithine decarboxylase (ODC) were performed on the brain tissue. Results of this study reveal that chronic exposure of rat to microwave radiation alter the activity of certain enzymes. There was a significant increase in calcium ion efflux and the activity of ODC. On the other hand, there is a significant decrease in PKC activity. Since these enzymes are related to growth, any alteration may lead to affect functioning of the brain and its development. |
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| Findings | Effects | |
| Status | Completed With Publication | |
| Principal Investigator | Jawaharlal Negru University, New Delhi, India - jbehari2000@yahoo.co.in | |
| Funding Agency | Private/Instit. | |
| Country | INDIA | |
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