ID Number		1007
Study Type		In Vivo
Model		2450 MHz (CW) exposure to rats and dogs and analysis of cerebral blood flow and blood brain barrier
Details		Rats were exposed to 2450 MHz (CW) to induce brain temperature increases as a model to induce hyperthermia, and then analyzed for temperature distribution, early histological changes, blood brain barrier (BBB) disruption and sequential changes in cerebral blood flow (CBF). Significant histological changes and BBB disruption were observed in brain regions heated to 43°C and above. CBF increased in the cortex after heating to 41-43°C, then returned gradually to the pre-hyperthermic levels. The authors reported a threshold for hyperthermia-induced cellular injury of above 43°C, which was associated with cerebral ischaemia. In an earlier and related study in dogs exposed to 8 MHz RF, thresholds for BBB disruptions were temperatures greater than 42°C for 45 minutes or 43°C for 15 minutes.
Findings		Effects (only at thermal levels)
Status		Completed With Publication
Principal Investigator		Yamaguchi University School of Medicine, Ube, Japa
Funding Agency		Private/Instit.
Country		JAPAN
References		Ohmoto, Y et al. Int. J. Hyperthermia, (1996) 12:321-334 Ikeda, N et al. Int. J. Hyperthermia, (1994) 10:553-561
Comments